The entry of cGAMP into cells can overcome the escape of cGAS recognition by pathogens (Li et al., 2013b), and activate the interferon response driven by STING in DCs, thereby promoting the formation of major histocompatibility complex presenting tumor-associated antigens to activate CD8+ T cells for antitumor killing (Li et al., 2016). This evidence concerns the gene CD8A and neoplasm.