The cGAS-STING pathway plays an important role in innate immunity, but cGAS can also be activated by the body’s abnormal DNA to cause tissue damage or autoimmune diseases, such as Aicardi-Goutières syndrome (AGS), systemic lupus erythematosus (SLE), primary biliary liver disease. Here, STING1 is linked to Aicardi-Goutieres syndrome.