In the process of immune surveillance, cGAS can detect the DNA leaked into the cytoplasm during abnormal mitosis that often occurs in malignant cells, induce the secretion of IFN-I, which stimulates the presentation of tumor antigens, and activates tumor-specific CD8+ effector T cells to exert the antitumor effect (Duewell et al., 2014). Here, CD8A is linked to neoplasm.