NO2-FAs forms a covalent bond with Cys88/91 and N-terminal His16, which affects the palmitoylation of STING and inhibits TBK1 phosphorylation in the fibroblasts derived from patients of STING-associated vascular disease (SAVI). This evidence concerns the gene STING1 and STING-associated vasculopathy with onset in infancy.