Increasing evidence indicates that persistent activation of STING is associated with the pathogenesis of autoimmune diseases induced by its gene mutations, such as AGS (Barber, 2015), autoimmune myocarditis (Kwon and Bakhoum, 2020), multiple arthritis, and other related vascular diseases (Feng et al., 2020). The gene discussed is STING1; the disease is autoimmune disease.