Non-T2DM vs SGLT2-I users, and non-T2DM vs non-SGLT2-I users had the lowest values of IL-1, IL-6, and TNF-α (p < 0.05); these inflammatory markers were over-expressed in non-SGLT2-I users as compared to SGLT2-I users (p < 0.05) Table 1. This evidence concerns the gene TNF and type 2 diabetes mellitus.