For future research, whether necroptosis can be used as a new potential pathway for the treatment of depression still needs to be confirmed with RIPK or MLKL knockout mice, and the functional impact of necroptosis in depression with the specific role of the active components of Xiaoyaosan on neuroinflammation could be further explored by more novel and accurate network pharmacological analysis. Here, MLKL is linked to depressive symptom measurement.