EGFR and malignant colon neoplasm: In colon cancer, curcumin combined with 5-fluorouracil (5-FU) and oxaliplatin (FOLFOX) were found to induce higher levels of apoptosis by reducing both the expression and activation of EGFR, IGF-1R, HER-2, and HER-3 by a greater magnitude then either agent alone (Patel et al., 2008).