MAPK3 and triple-negative breast carcinoma: Meanwhile, in triple negative breast cancer (TNBC) cells curcumin did not alter the expression of EGFR and ERK1/2 however, it significantly reduced the levels of phosphorylated EGFR and ERK1/2, showing that it specifically inhibits activation of EGFR and its downstream signaling molecules to reduce cell proliferation (Sun et al., 2012).