IGF1R and breast cancer: Moreover, overexpression of IGF-1R also decreases tumour latency time, increases the proliferative genetic signature and enhances migration potential in mammary tumours in addition to protecting cells against stresses of the tumour microenvironment and apoptosis (Resnicoff et al., 1995; Valentinis and Baserga, 1996; Peretz et al., 2002; Ter Braak et al., 2017).