In cancer, there are four common genetic events that drive cancer progression which include 1) PIK3CA activating mutations, 2) PTEN loss-of-function mutations and deletions, 3) gain-of-function mutations in Akt-encoding genes, and lastly 4) amplification of RTKs that activate PI3K signaling (Hoxhaj and Manning, 2020). Here, AKT1 is linked to cancer.