Alterations in PPARα target gene expression may be causative to a decrease in fatty acid oxidation but an increase in fatty acid uptake, which subsequently accounts for the severe hepatic lipidosis observed in mice and cell culture experiments (Gu et al., 2003; Henderson et al., 2003; Weng et al., 2005; Porter et al., 2011). The gene discussed is PPARA; the disease is lysosomal lipid storage disorder.