Only three proteins were found with significantly higher expression in HepaRG−POR#2 cells, fetuin-A AHSG (FETUA), a protein associated with obesity and insulin resistance, RL7L, a ribosomal protein involved in ribosomal biogenesis, and prothrombin F2 (THRB) involved in thrombosis and hemostasis during blood clot formation. This evidence concerns the gene THRB and obesity due to melanocortin 4 receptor deficiency.