BCR and chronic myelogenous leukemia, BCR-ABL1 positive: As shown in Figures 7A–D, the mRNA expression of AGEs, CML, CEL and RAGE was significantly increased in 12-month-old mice compared with 2-month-old normal young mice [AGEs: F (3, 20) = 76.43, p < 0.01; CML: F (3, 20) = 82.39, p < 0.01; CEL: F (3, 20) = 43.16, p < 0.01; RAGE: F (3, 20) = 55.64, p < 0.01].