Some data suggest that two common antihypertension medications (angiotensin II receptor antagonists, ARBs; and angiotensin-converting-enzyme inhibitors, ACEIs) may increase ACE2 expression in heart and kidney cells (Tikellis et al., 2003; Ferrario et al., 2005a; Ferrario et al., 2005b; Ocaranza et al., 2006; Yang et al., 2013; Zhang et al., 2014), fueling debate early in the COVID-19 pandemic about how these widely used medications might modulate SARS-CoV-2 infectivity and the risk of COVID-19. This evidence concerns the gene ACE2 and COVID-19.