ACE2 and lung disorder: In some animal studies ARBs and ACEIs were observed to increase ACE2 expression in some tissues (Tikellis et al., 2003; Ferrario et al., 2005a; Ferrario et al., 2005b; Ocaranza et al., 2006; Yang et al., 2013; Zhang et al., 2014), but the impact of these drugs on ACE2 expression in humans is mixed (Sriram and Insel, 2020), and ACE2 was found to be protective against pulmonary disease from SARS-CoV in mice (Altman et al., 2017).