In the formula, the active components of CRr and CPr show a strong anti-microbe activity (Wang and Ng, 2001; Li et al., 2005; Kim et al., 2014; Tian et al., 2020) and suppress subsequent inflammatory responses (Kubo et al., 1994; Wang and Ng, 2001) and neoplasias (Peng et al., 2006; Chen et al., 2016; Wan et al., 2019). This evidence concerns the gene POR and neoplasm.