In contrast to miR-210, which inhibited oxidative phosphorylation and enhanced mitochondrial reactive oxygen species production, miR-383 increased ATP levels and inhibited necroptosis by suppressing poly(ADP-ribose) glycohydrolase (Parg), which enhanced atherosclerosis (Karshovska et al., 2020) (Figure 4B). This evidence concerns the gene PARG and atherosclerosis.