CASP3 and colorectal carcinoma: As shown in Figures 8G,H , PM extract inhibited the expression of RelA, Bcl2, caspase 3, and CCND1 and promoted apoptosis-related proteins Bax, cleaved caspase 3, and EGFR. These results confirmed that PM extract is mainly involved in inhibiting CRC through apoptosis-related pathways, especially the NF-κB pathway in which RelA is engaged.