Taken together, our results demonstrated that continued administration of 9-PAHSA alleviated diabetic cardiomyopathy in db/db mice.9-PAHSA treatment increased cardiac autophagy possibly via up-regulation of PI3KIII and BECN1 and down-regulation of mTOR and p-Akt in diabetic myocardium (Figure 8). Here, MTOR is linked to diabetic cardiomyopathy.