Prior to the development of the mouse lines expressing human SCN8A epilepsy mutations, most of the published Scn8a mouse models carried loss-of-function missense or truncating Scn8a mutations (Martin et al., 2007; Papale et al., 2009; Hawkins et al., 2011; Makinson et al., 2014). This evidence concerns the gene SCN8A and epilepsy.