This variant is not observed in the gnomAD database (v3.1.1), and it is adjacent to several reported variants associated with epileptic encephalopathy, including p.L1865P (Trump et al., 2016), E1870D (Boerma et al., 2016), and R1872 which is one of the most frequently mutated SCN8A residues (Ohba et al., 2014; Larsen et al., 2015; Wagnon et al., 2016). Here, SCN8A is linked to Epileptic encephalopathy.