Stringer and others recently described a patient with epileptic encephalopathy who harbors a de novo heterozygous in-frame duplication in SCN8A (p.G1625_I1627dup) and an inherited heterozygous missense variant in CACNA1H (p.G318S) (Stringer et al., 2021). The gene discussed is SCN8A; the disease is Epileptic encephalopathy.