Moreover, STAT3 is specifically associated with the promoter of HOXD-AS1 and then activates HOXD-AS1 transcription, resulting in a poor prognosis and advanced stage of lymph node metastasis in hepatocellular carcinoma patients (Wang et al., 2017b). The gene discussed is HAGLR; the disease is metastatic malignant neoplasm in the lymph nodes.