- significant correlation between the ratio of quinine/3-OH-quinine and median CRP (r = 0.48, p = 0.001), orosomucoid (r = 0.44, p = 0.003) and IL-6 after 12 h after drug intake (r = 0.43, p = 0.004), - correlation is no longer significant for IL-6 and orosomucoid after adjustment for age, gender, diabetes mellitus, dialysis vintage, PTH, orosomucoid and medications and it remains borderline for CRP (r = 0.05). The gene discussed is CRP; the disease is diabetes mellitus.