CYP3A4 and Decreased total neutrophil count: - high midazolam concentration and free docetaxel AUC were associated with sever neutropenia (and conversion to febrile neutropenia), - high midazolam concentration was correlated with elevated ferritin level (r = 0.32, p = 0.02) (indicator of an inflammatory state), - according to authors, inflammation favors a reduction in CYP3A activity and thus, could lead to an overexposure to its substrates