PPIG and liver disorder: - mean value of hepatic CYP concentration did not differ between patients with mild to moderate hepatocellular changes (less than 50% hepatocytes morphologically abnormal) or inactive cirrhosis and controls and antipyrine half-life did not significantly differ between all groups, - CYP concentration was less in patients with severe liver disease (more than 50% hepatocytes morphologically abnormal or active cirrhosis) and, thus, antipyrine half-life was significantly lower (p < 0.01) compared to other groups