CYP3A4 and type 2 diabetes mellitus: One study using a cocktail approach showed that CYP2B6, CYP2C19 and CYP3A activity decreased, CYP1A2 and CYP2C9 activity increased, and CYP2D6 and CYP2E1 activity was unaffected in type II diabetes (T2D) (Gravel et al., 2019).