However, type I (T1D) and type II diabetes did not appear to have the same impact on CYP metabolism (Dyer et al., 1994; Korrapati et al., 1995; Lucas et al., 1998; Zysset and Wietholtz, 1988; Matzke et al., 2000; Sotaniemi et al., 2002; Wang et al., 2003). Here, PPIG is linked to type 1 diabetes mellitus.