PPIG and AIDS: In most studies, significant changes in CYP activities occurred in the presence of severe inflammation, characterized by elevated levels of inflammatory markers or a severe disease state, such as AIDS, advanced cancer or polytrauma patients (Gatti et al., 1993; Lee et al., 1993; Farrell et al., 1979; Grieco et al., 1998; Bauer et al., 1994; Harbrecht et al., 2005; Charles et al., 2006; Alexandre et al., 2007; Helsby et al., 2008; Abou Farha et al., 2012; ten Bokum et al., 2015; Hefner et al., 2015; Yasu et al., 2017; Gautier-Veyret et al., 2019).