- the apparent clearances of both nisoldipine enantiomers in the hypertensive patients with T2D are significantly lower than in hypertensive control patients (p < 0.05), - higher ratio of plasma lidocaine/MEGX concentration for diabetic group than in control group (p < 0.05), - means that CYP3A4 activities were decreased in the diabetic groups, - significant correlations were found (p < 0.05) between the MR of lidocaine and the apparent clearance of nisoldipine enantiomers obtained for both groups. Here, CYP3A4 is linked to type 2 diabetes mellitus.