- in non-tumorous liver fragment removed with the tumor in each patients, authors observed that CYPs proteins (CYP1A2, 2C, 2E1 and 3A), monooxygenase activities of methoxyresorufin and erythromycin and total CYPs were significantly decreased only in the group of patients treated with highest doses of IL-2, compared to control. Here, CYP1A2 is linked to neoplasm.