- the MR (losartan/E-3174) significantly increase (p = 0.002) compare to controls already included who genetic variants and losartan oxidation were already known, - in patients with the wild type CYP2C9 genotype (*1/*1), the MR significantly increased in patients with Behçet’s disease compared to controls (p = 0.006) but there is no significant differences found for other CYP2C9 genotype. The gene discussed is CYP2C9; the disease is Behcet disease.