IL1B and primary progressive multiple sclerosis: Numerous studies have demonstrated that there are gene variations and polymorphisms in the IL1B gene and that these variants could influence the transcription and expression of the IL1B gene and are specifically correlated with many autoimmune and inflammatory diseases, including systemic lupus erythematosus (SLE) (Mohammadoo-Khorasani et al., 2016), antisynthetase syndrome (ASSD) (Ponce-Gallegos et al., 2020), rheumatoid arthritis (RA) (Hu et al., 2020) and primary progressive multiple sclerosis (Malhotra et al., 2020).