NAT2 and colorectal carcinoma: Furthermore, a forest plot was constructed to display the hazard ratio of NAT2 and clinical features (age, gender, stage, and grade), which suggested that NAT2 could be an independent clinical risk factor in CRC (hazard ratio for death, 0.06; 95% CI, 0.01 to 0.59; p = 0.02; Figure 4).