SESN2 and cardiac hypertrophy: Lately, Nanhu Quan et al. reported that Sesn2 deficiency exaggerated pressure overload or age-induced mouse cardiac hypertrophy and dysfunction (Quan et al., 2020), and adeno-associated virus 9-mediated Sesn2 overexpression in the mouse heart could attenuate these changes via interacting with GATOR2 and thus inhibiting mTORC1 activity (Quan et al., 2020).