Moreover, Nrf-2-inducing drugs have beneficial effects on diseases such as obesity, diabetes, arteriosclerosis, neurodegenerative diseases, and tumorigenesis (Joshi and A. Johnson, 2012; Magesh et al., 2012; Suzuki et al., 2013). This evidence concerns the gene NFE2L2 and obesity due to melanocortin 4 receptor deficiency.