In IL-1β–induced A549 lung carcinoma cells expressing highly active COX-2 as published previously (Petkova et al., 2004), no COX-2 inhibition by 10 μM 9NOA or derivative 20.9.9 could be observed as compared to the control OA (Supplymentary Figure S5A). Here, PTGS2 is linked to lung carcinoma.