MAPK8 and breast cancer: Besides, the “medical plant” induces apoptosis in human breast cancer MDA-MB-231 cells via sustainable activation of C-Jun NH2-terminal kinase (JNK) and MAPK, and mitochondrial-mediated apoptosis pathway, which suggests that Catha edulis has substantial potential as a source of anticancer agents (Bredholt et al., 2009; Lu et al., 2017).