CD4+CD25−CD62L+ T cell transfer into SCID mice induced colitis (Figure 3A) that was manifested by weight loss (Figure 3B), colon elongation, and by mucosal inflammation accompanied by crypt loss due to lymphoid infiltration into the crypt epithelium, diffuse crypt elongation with increased crypt proliferative zone, and reduced goblet cell number (Figure 12B) and was reflected through a total histology activity score (Figure 3C; Supplementary Table S1C). The gene discussed is CD4; the disease is colitis.