Although one study reported that microglia depletion by PLX3397 exacerbated seizure severity and excitotoxicity-induced neuronal degeneration (Liu M. et al., 2020), other studies predicted CSF1R to be a potential target for anti-epileptic drugs (Lyman and Chetkovich, 2019; Gerard et al., 2021) as CSF1R blockade attenuating epilepsy seizures has been validated in three pre-clinical models of epilepsy (Srivastava et al., 2018). The gene discussed is CSF1R; the disease is epilepsy.