Although CSF1R is associated with different malignant diseases (Cassier et al., 2015; Cannarile et al., 2017), mutations in CSF1R result in a neurodegenerative disease named adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), which is characterized by executive dysfunction, memory decline, personality changes, motor impairments, and seizures (Chitu et al., 2021). The gene discussed is CSF1R; the disease is neurodegenerative disease.