MAPT and Alzheimer disease: Typical pathological features in the brain of the patients with AD are beta-amyloid (Aβ) plaques, intracellular neurofibrillary tangles consisting of hyper-phosphorylated tau fibrils, degeneration of neurons, and loss of synapses, neuroinflammation, and glial activation (Bronzuoli et al., 2016).