CEBPZ and Alzheimer disease: During both ischemic injury and AD, ECs have been observed to decrease NO production, causing dysregulation of CBF (Morikawa et al., 1994; Biernaskie et al., 2001; Girouard and Iadecola, 2006; Austin et al., 2013; Parodi-Rullán et al., 2019; Freitas-Andrade et al., 2020).