Enhancing intracellular cAMP level, inhibit microglia-mediated neuroinflammation, activating classical cAMP/PKA/CREB as well as the PI3K and p38 MAPK signaling pathways, β2AR/β-arrestin2-dependent pathway, inhibiting microglial activation in LPS-challenged inflammatory PD mouse model. Here, ADRB2 is linked to Parkinson disease.