Kou et al. (2021) found that ApoE4 transgenic mice had impaired cognitive capacity, which is linked to ER stress and activation of inflammatory signaling in the nervous system; these were reversed by curcumin treatment in AD mice. Curcumin is also found effective in Pelizaeus-Merzbacher disease of mice model (Gow et al., 1998; Hübner et al., 2005; Yu et al., 2012). Here, APOE is linked to Alzheimer disease.