FOLH1 and multiple sclerosis: GCPII inhibitors have beneficial effects in a number of inflammatory and/or excitotoxic conditions (Carpenter et al., 2003; Berent-Spillson et al., 2004; Neale et al., 2005; Zhang et al., 2006; Rahn et al., 2012; Wozniak et al., 2012; Nonaka et al., 2017), including improving learning and memory in a mouse model of multiple sclerosis (Rahn et al., 2012), while genetic knockout of GCPII protects cortical and hippocampal neurons against traumatic brain injury (Cao et al., 2015, 2016).