Administration of GCPII inhibitors to rodents has previously been shown to improve performance of tests of learning and memory that depend on the hippocampus (Janczura et al., 2013), including in mouse models of AD and substance abuse (Olszewski et al., 2017) or of multiple sclerosis (Rahn et al., 2012; Hollinger et al., 2016). Here, FOLH1 is linked to multiple sclerosis.