As GCPII expression is increased by inflammation (Neale et al., 2005; Cao et al., 2015, 2016; Zhang Z. et al., 2016), and during drug withdrawal (Hicks et al., 2017), GCPII inhibition has therapeutic potential for a range of cognitive disorders associated with inflammatory and dysregulated etiologies. This evidence concerns the gene FOLH1 and Cognitive impairment.