Longitudinal studies have emphasized that Aβ deposition in the precuneus and other cortical regions comprising the DMN in the pre-dementia stage would sequentially induce regional cortical hypometabolism, accumulation of tau pathology, and hippocampal volume loss (Gordon et al., 2016, 2018; Hanseeuw et al., 2019). The gene discussed is MAPT; the disease is dementia.