MAPT and myotonic dystrophy type 1: In the DM1 brain, dysregulation of alternative splicing could lead to pathologic Tau proteins accumulations and the formation of neurofibrillary tangles (NFTs) (Caillet-Boudin et al., 2014), which are mainly located in the HPC, entorhinal cortex, and most of the temporal areas, called Tau pathology.