Further, Mbnl2–/– mice which are exposed to sleep deprivation also developed several CNS features including impaired long-term potentiation (LTP), deficits in spatial memory, reduced synaptic NMDAR response and impaired hippocampal synaptic plasticity (Charizanis et al., 2012), which were similar to the DM1 phenotype. Here, MBNL2 is linked to myotonic dystrophy type 1.