MBNL1 and myotonic dystrophy type 1: A large amount of previous studies have revealed the critical role of MBNL proteins in muscle or heart-related disorders, while in recent years, a close relationship between the loss-of-function of MBNL and DM1 brain-related phenotypes were also detected (Matynia et al., 2010; Charizanis et al., 2012; Goodwin et al., 2015), especially MBNL2.