PRRT2 and myotonic dystrophy type 1: In recent years, other factors, such as repeat-associated non-AUG (RAN) translation, which can contribute to the formation of toxic homopolymeric (e.g., polyQ) polypeptides, aberrant polyadenylation, activation of protein kinase C (PKC)-dependent signaling pathway, and microRNA deregulation have also been reported to play important roles in DM1 (Chau and Kalsotra, 2015).