Besides, increased levels of total-Tau, IgG, γ-globulin, and myelin basic protein (MBP), as well as decreased levels of Aß1-42 and orexin-A were found in the CSF of DM1 patients (Hirase and Araki, 1984; Martínez-Rodríguez et al., 2003; Winblad et al., 2008; Peric et al., 2014a). The gene discussed is HCRT; the disease is myotonic dystrophy type 1.