Moreover, previous studies have also implicated the association between NCL and PD, including the evidence of the analysis of the brain tissues of Atp13a2 conditional-knockout mice (Sato et al., 2016) and the identification of the reduced dopamine transporter density in the striatum in juvenile NCL patients with parkinsonism (Aberg et al., 2000). This evidence concerns the gene NUCLEOLIN and neuronal ceroid lipofuscinosis.