MAPT and Cognitive impairment: Moreover, dietary supplementation with Eicosanoyl-5-hydroxytryptamide (EHT), a minor component of coffee, for 6–12 months in rats, substantially ameliorated cognitive impairment, tau hyperphosphorylation, and elevated levels of cytoplasmic Aβ, potentially through its ability to increase phosphoprotein phosphatase 2A (PP2A) activity.