MAPT and Alzheimer disease: The functions by which Hsp70 proteins protect against neuronal damage are speculated to stem from either direct binding to Aβ42, disruption of Aβ metabolism, or conformation changes preventing Aβ42 neurotoxic accumulation and modulating Tau degradation (Kumar et al., 2007; Sarkar et al., 2008; Rivera et al., 2018; Wang et al., 2021) suggesting that this protein family is chaperones with promising neuroprotective properties in AD.