Although macrophage-induced demyelination is the pathological characteristic in the majority of CIDP patients, recently, nodal and paranodal IgG4 autoantibodies against different antigens including neurofascin-186, neurofascin-155, contactin-1, and contactin-associated protein 1 have been described in classic CIDP as well as in some of its atypical forms (Lehmann et al., 2019; Koike and Katsuno, 2020; Ogata, 2020). This evidence concerns the gene CNTN1 and chronic inflammatory demyelinating polyradiculoneuropathy.