NR3C1 and post-traumatic stress disorder: The idea that, in PTSD and PTSD models, the GR functionality is changed beyond the negative feedback sensitivity goes back to human studies on lymphocyte GR expression (Yehuda et al., 1991), and, in rodent models, it has logically been extended to higher brain centers, which may be involved in the actual psychopathological symptoms of PTSD (Eagle et al., 2013).