MAPT and Alzheimer disease: Also, several reports suggest that the ratio of Aβ1–42/Aβ1–40 (Blennow and Hampel, 2003), t-tau/Aβ1–42 (Shaw et al., 2009) or p-tau/Aβ1–42 (De Meyer et al., 2010) more accurately reflect AD pathology than Aβ1–42 or tau alone.