After EA intervention, the results in Figure 4B showed that the glucose metabolism in the right hippocampus of the AD group was decreased compared with the WT group (P < 0.05); the glucose metabolism in the hippocampus (left and right) of the AD + AMPK(+/–) group were decreased compared with the WT group (P < 0.05 and P < 0.01). The gene discussed is PRKAA1; the disease is Alzheimer disease.