PRKAA1 and Alzheimer disease: The escape platform crossing times and the 3rd quadrant time proportion in the AD group were decreased compared with the WT group (P < 0.05); the AD + EA group increased compared with the AD group (P < 0.05); the AD + AMPK(+/–) + EA group increased compared with the AD + AMPK(+/–) group (P < 0.05) (Figures 3B,C).