Within ALS, protein aggregates of TAR DNA-binding proteins 43 (TPD-43), superoxide dismutase type-1 (SOD1), and RNA-binding protein fused in sarcoma (FUS) are linked to mitochondrial dysfunction and degeneration, impaired UPS, and reduced autophagy (Chisholm et al., 2021). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.