In a somewhat conflicting manner, TRAF6 plays roles in neuronal survival and activity, which include Aβ-neurotrophin receptor P75 (Aβ-p75NTR) pathways and spinogenesis, suggesting that inhibition of TRAF6 would be detrimental to AD patients (Geetha et al., 2012). This evidence concerns the gene TRAF6 and Alzheimer disease.