In PD patients, NEDD4-1 is expressed in neurons that contain Lewy Bodies and ubiquitinates α-syn via K63-linked ubiquitin, leading to α-syn degradation via the lysosomal pathway (Tofaris et al., 2011; Huang et al., 2019; Farrawell et al., 2020). This evidence concerns the gene NEDD4 and Parkinson disease.