Within ALS, protein aggregates of TAR DNA-binding proteins 43 (TPD-43), superoxide dismutase type-1 (SOD1), and RNA-binding protein fused in sarcoma (FUS) are linked to mitochondrial dysfunction and degeneration, impaired UPS, and reduced autophagy (Chisholm et al., 2021). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.