MARCHF8 and Alzheimer disease: Guo et al. (2019) demonstrated that siRNA specific to MARCH8 decreases apoptosis following TNF-α treatment (Frost et al., 2019). Overexpression of MARCH8 in AD can result in downregulation of several immunomodulatory receptors, impaired development of immune cells, and resultant immune suppression (Samji et al., 2014).