In the context of ALS, TRAF6 is localized to the mitochondria in the spinal cord of rats and interacts with mutant SOD1 variants SOD1A4V and SOD1V148G leading to polyubiquitination and/or aggregation of SOD1 that results in cellular accumulation (Semmler et al., 2020). This evidence concerns the gene TRAF6 and amyotrophic lateral sclerosis.