Considering the oxidative stress in FXS, it is interesting to underline that El Bekay et al. (2007) found that Fmr1 KO mouse brains have higher levels of reactive oxygen species, nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase activation, lipid peroxidation and protein oxidation compared to wild type mice. This evidence concerns the gene FMR1 and fragile X syndrome.