Besides, upregulation of Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) and Cerebral Dopamine Neurotrophic Factor (CDNF) in astrocytes was observed in the experimental model of stroke, which alleviates the damage of endoplasmic reticulum stress (Shen et al., 2012; Cheng et al., 2013; Zhao et al., 2013). This evidence concerns the gene MANF and Stroke.