When gene expression analysis was performed comparing high-grade gliomas (GBM) with all low-grade glioma (LGG) subtypes combined and independent of the level of TMEM230 (Supplementary Figure 5 and Supplementary Table 6), pathways identified with high and low TMEM230 (Supplementary Figures 1-4) were a subset, as expected. Here, TMEM230 is linked to central nervous system cancer.