Analysis was also performed to identify specific pathways correlated with different expression levels of TMEM230 in low grade (G2) and high grade (G3) astrocytoma (Supplementary Figures 8, 9 and Supplementary Tables 9, 10) and high grade GBM and astrocytoma independently of the level of TMEM230 (Supplementary Figure 7 and Supplementary Table 8) and in GBM and astrocytoma, oligoastrocytoma and oligodendroglioma (Figures 8A-C and Supplementary Tables 11, 12). The gene discussed is TMEM230; the disease is astrocytoma (excluding glioblastoma).