TMEM230 and neoplasm: The ability of TMEM230 to promote tumor cell migration and displacement of endothelial cell to cell contacts as an early step in blood vessel disruption was accessed by determining whether TMEM230 expressing U87 cells can invade into endothelial cells, displace endothelial cell-cell contacts and cell-ECM scaffold interactions, using co-culture assays of U87 and HUVEC cells.