Insight into the molecular components of these 3 mechanisms is provided by gene expression analysis obtained from patients with glial tumors (Supplementary Figures and Tables) and the observation that expression of TMEM230 in GBM is positively correlated with increased expression of genes and pathways associated with extracellular vesicles, angiogenesis, cell adhesion and motility. The gene discussed is TMEM230; the disease is glioma.