Especially, mutations in DHHC PATs are related to neurogenerative diseases (DHHC7, DHHC12, and DHHC21 in Alzheimer’s disease, DHHC17/HIP14 (huntingtin-interacting protein 14) and DHHC13/HIP14L (HIP14-like) in Huntington’s disease) and mental disorders (DHHC5 in bipolar disorder, DHHC8 in schizophrenia, DHHC9, and DHHC15 in X-linked intellectual disability). Here, ZDHHC17 is linked to early-onset autosomal dominant Alzheimer disease.