The enrichment of Cα in this region is especially interesting because it provides a novel opportunity to study the disease mechanisms of Usher syndrome, a complicated disease previously linked to the cAMP pathway that is defined by several mutations of cilia-associated proteins (Kremer et al., 2006; Mathur and Yang, 2015), as well as other blinding diseases that arise from improper regulation of the outer segment sensory cilium (Wensel et al., 2016). Here, CYS1 is linked to Usher syndrome.