CLDN5 and multiple sclerosis: In addition, claudin-5 remodeling occurs at sites of leukocyte transmigration in both physiological and pathological conditions such as Multiple Sclerosis (Paul et al., 2013; Winger et al., 2014; Castro Dias et al., 2021) and mislocalization of claudin-5 occurs in a mouse model of oxygen induced retinopathy (Luo et al., 2011).