Almost all families show dominant inheritance of non-syndromic autosomal OA and rod-cone dystrophy in addition to the optic atrophy is common, indicating that retinal neurons other than RGCs are susceptible to mitochondrial dysfunction induced by SSBP1/OPA13 mutations (Jurkute et al., 2019; Del Dotto et al., 2020). Here, SSBP1 is linked to cone-rod dystrophy.