Almost all families show dominant inheritance of non-syndromic autosomal OA and rod-cone dystrophy in addition to the optic atrophy is common, indicating that retinal neurons other than RGCs are susceptible to mitochondrial dysfunction induced by SSBP1/OPA13 mutations (Jurkute et al., 2019; Del Dotto et al., 2020). The gene discussed is SSBP1; the disease is Rod-cone dystrophy.