AQP4 and Alzheimer disease: Grubman et al. (2019) performed snRNA-seq of entorhinal cortex from deceased patients with Alzheimer’s disease and age-matched healthy controls and got 13,214 nuclear, with a median of 646 genes per cell. With AD autopsy cases, Mathys et al. (2019) performed snRNA-seq of frozen human tissues and identified major types of cells in the brain: excitatory neurons (NRGN+), inhibitory neuron (GAD1+), astrocyte (AQP4+), oligodendrocyte (MBP), microglia (CSF1+ and CD74+), oligodendrocyte progenitor cells (VCAN+), endothelial cells and pericytes (AMBP+).