Collectively, our analysis suggested DElncRNAs might promote caspase-dependent apoptosis through MAPK8/JNK signaling pathway in the course of epilepsy, which have been confirmed by several previous studies in epileptic rat models (Wu and Yi, 2018; Xiao et al., 2018; Luo et al., 2019). This evidence concerns the gene MAPK8 and epilepsy.