CXCL1 and ischemic stroke: In addition to MCPIP1-mediated inflammatory responses, ZEB1 (C2H2 type) in microglia after ischemic stroke can reduce neutrophils infiltration into ischemic brain by reducing the production of C-X-C motif ligand 1 (CXCL1) in astrocytes (CXCL1 is a chemokine that mainly absorbed neutrophil), thereby alleviating nerve injury (Li et al., 2018).