The development of AD is associated with mutations in the DNA intron that codes for GLIS3: A genome-wide association study of cerebrospinal fluid (CSF) tau/ptau levels has shown that mutations in rs514716 in DNA introns encoding GLIS3 were more likely to lead to endomorphic AD (Cruchaga et al., 2013; Calderari et al., 2018). This evidence concerns the gene MAPT and Alzheimer disease.