a. CIZ1 induces the cytoplasmic export of CDKN1A (p21 CIP1), blocking the onset of S phase and leading to disruption of cell function in AD. b. The protein encoded by CIZ1 is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. This evidence concerns the gene PRDM2 and Alzheimer disease.