IL6 and ischemic stroke: After an ischemic stroke occurs, KLF11 functions at microvascular endothelial cells to promote tight junction proteins activities and reduce the expression of pro-inflammatory factors—IL-6 (Fan et al., 2012), and maintain the structural and functional integrity of BBB (Neve et al., 2005; Fernandez-Zapico et al., 2009; Zhang et al., 2020), thus providing brain protection in ischemic stroke.