PRKN and Parkinson disease: Several independent studies have shown PINK1/Parkin-dependent accumulation of Ras-related protein Rab-10 (RAB10), an LRRK2 substrate, on damaged mitochondria in PD patients with the LRRK2 G2019S mutation, suggesting that LRRK2 is involved in PINK1/Parkin-mediated mitophagy (Bonello et al., 2019; Wauters et al., 2020).