Proteins altered in ALS, such as superoxide dismutase 1 (SOD1), TAR DNA binding protein (TDP43), fused in sarcoma (FUS), and C9orf72, have been implicated in a wide range of cellular pathways (Bruijn et al., 1997; Neumann et al., 2006; Vance et al., 2009; Cooper-Knock et al., 2012). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.