In Tau and APP-expressing neuroblastoma cells, overexpression of P301L mutant Tau or mutant APPswe impairs the translocation of mitochondrial Parkin, PINK1, LC3-II/I, and other mitophagy-related proteins (Ye et al., 2015; Cummins et al., 2019). The gene discussed is PINK1; the disease is neuroblastoma.