Therefore, we first determined the correlation between TREM2 and microglial activation in PD progression and showed that the expression of TREM2 could both inhibit the activation of microglia by inhibiting the p38 MAPK pathway and induce an increase in microglial autophagy by inhibiting the mTOR pathway, thereby reducing to reduce the pathological damage process of PD, protect dopaminergic neurons and improve motor symptoms of mice. The gene discussed is MTOR; the disease is Parkinson disease.