In addition, many studies have shown that common abnormal mutations in PD-linked genes, such as SNCA (alpha-synuclein), can lead to the imbalance of autophagy and accelerate the progression of disease, which should be the reason for the decrease in basic autophagic activity that has been observed in patients with PD (Senkevich and Gan-Or, 2020). Here, SNCA is linked to Parkinson disease.