CD68 and Alzheimer disease: Indeed, increased markers of microglial activation, such as major histocompatibility complex II (MHCII) and CD68, are noted in AD-relevant brain regions such as the entorhinal cortex, frontal and temporal gyri, hippocampus, and frontal, temporal and occipital cortices in post-mortem AD brain tissue (Gomez-Nicola and Boche, 2015; Hopperton et al., 2017).