Given youth with obesity are at increased risk of cardiometabolic disorders in adulthood, and BDNF has been implicated in energy intake and metabolic dysregulation as described above, future research is needed to verify our findings and determine whether carriers of this BDNF polymorphism are genetically predisposed for increased energy intake, weight gain and metabolic complications. This evidence concerns the gene BDNF and obesity due to melanocortin 4 receptor deficiency.